Endoscopic Findings of Gastric Extranodal Marginal Zone B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma

Approximately 360,000 new cases of non-Hodgkin’s lymphoma were diagnosed worldwide in 2014. Of these, approximately 7% were diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric extranodal marginal zone B-cell MALT lymphoma accounts for 1%–7% of malignant gastric tumors and 60%–75% of gastrointestinal MALT lymphomas. Gastric MALT lymphoma shows various endoscopic findings. The structure and function of gastric MALT are similar to those of Peyer’s patches in the terminal ileum. Gastric MALT originates in subepithelial layers, usually in the stromal space, and grows under the normal gastric foveolar glands. Thus, both mucosal and submucosal lesions can be found on endoscopic examination. Therefore, the histologic diagnosis of lymphoma is often unexpected, even to an experienced endoscopist. Taal et al. attempted to classify the endoscopic findings in gastric MALT lymphoma into several categories. Thereafter, several classification systems based on gross morphology were suggested. However, there have been no generally accepted classification criteria, because the clinical implications of endoscopic categorization of gastric MALT lymphoma are still unclear. Advanced stage, gene translocation t(11;18) (q21;q21), and non-responder (no change) MALT lymphomas that persist after successful Helicobacter pylori eradication are associated with poor prognosis. In addition to those factors, Lee et al. in this issue of Clinical Endoscopy, concluded that the endoscopically defined polypoid type is associated with poor prognosis, and is characterized by a longer duration to complete response (CR), with a higher likelihood of recurrence, compared to the endoscopically defined diffuse infiltration or ulceration types. However, caution is needed when interpreting the results of this study. Even though the authors stated that there was no significant colinearity between endoscopic findings, Ann Arbor stage, and/or treatment, one of the three variables could be a potential confounding factor, as the authors suggested. With reference to their data summarized in the table, polypoid lesions are more likely to be diagnosed at an advanced Ann Arbor stage, as compared to diffuse infiltration or ulceration types. In a review of previous reports, Yokoi et al. suggested that the pathogenesis of polypoid gastric MALT lymphoma has little association with H. pylori infection. However, the results of this study are different from those in Yokoi’s report. Thus, it is still uncertain whether there is a reasonable explanation for a causal relationship between polypoid gastric MALT lymphoma and poor prognosis. We hope that a follow-up study can demonstrate a correlation between polypoid MALT lymReceived: December 15, 2016 Revised: January 18, 2017 Accepted: January 18, 2017 Correspondence: Sang Kill Lee Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea Tel: +82-2-2228-2272, Fax: +82-51-244-8180, E-mail: [email protected]